BioCAT is offering its second MuscleX workshop. The Biophysics Collaborative Access Team (BioCAT) is funded by National Institutes of Health (NIH) with its mission to operate state-of-the-art x-ray facilities for the study of the structure and dynamics of biological systems under non-crystalline conditions similar to their functional states in living tissues. We will have a series of introductory presentations of the scientific missions supported at BioCAT as well as a series of talks highlighting recent muscle studies using x-ray diffraction and scattering.
The workshop will take place from 5/20/21 to 5/21/21 and is entirely virtual (via BlueJeans). See the schedule below for details.
Registration
All participants this year will be remote participants. There is no cost associated with the workshop, but registration is required for administrative purposes.
How to register
More information
Workshop topics:
- Introduction to BioCAT
- Introduction to muscle x-ray diffraction capabilities at BioCAT
- Introduction of solution small angle x-ray scattering (SAXS) and its application to muscular proteins
- Science highlights from recent muscle studies using x-ray diffraction and scattering
If you have questions, please contact Weikang Ma (wma6@iit.edu).
Confirmed speakers:
- Thomas Irving (BioCAT, APS)
- Weikang Ma (BioCAT, APS)
- Srinivas Chakravarthy (BioCAT, APS)
- Elisabetta Brunello (King’s College London)
- Cameron Hill (King’s College London)
- Johan Lindqvist (U Arizona Tucson)
- Raúl Padrón (U Mass Medical School)
- Momcilo Prodanovic (U. Kragujevac, Serbia)
- Coen Ottenheijm (Amsterdam UMC)
- Massimo Reconditi (U Florence)
- Mike Regnier (U Washington Seattle)
Tentative schedule
Note: All times are Central Daylight Time (UTC-5)
Thursday 5/20/21
| 09:30 am | Welcome and introduction to BioCAT | Thomas Irving |
| 09:50 am | Muscle x-ray diffraction program at BioCAT | Weikang Ma |
| 10:30 am | Myosin-based regulation in the heart muscle | Elisabetta Brunello |
| 11:10 am | X-ray diffraction reveals the effect of nebulin on thin filament structure and how nebulin mutations cause thin filament dysfunction | Johan Lindqvist |
| 11:50 am | Break | |
| 12:20 pm | SAXS and its application to muscle proteins | Srinivas Chakravarthy |
| 01:00 pm | X-ray diffraction studies on the myosin interacting-heads motif of tarantula skeletal muscle | Raúl Padrón |
| 01:40 pm | Changes in myosin structure with 2-deoxy ATP a potential small molecule therapeutic for heart failure | Mike Regnier |
| 02:20 pm | Breakout Sessions for Discussion | |
| 03:00 pm | End of day 1 |
Friday 5/21/21
| 09:30 am | Modeling of x-ray patterns by MUSICO | Momcilo Prodanovic |
| 10:10 am | The super-relaxed state and length dependent activation in porcine myocardium | Weikang Ma |
| 10:50 am | Diaphragm pathology in critically ill patients | Coen Ottenheijm |
| 11:30 am | Temperature effects on thick filament structure | Massimo Reconditi |
| 12:10 pm | Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle | Cameron Hill |
| 12:30 pm | Breakout Sessions for Discussion | |
| 01:10 pm | End |