The BioCAT team, led by Prof. Thomas Irving (Illinois Institute of Technology) has been awarded $2 million in supplementary funds from the National Institutes of Health to upgrade the BioCAT beamline. These funds will let us upgrade our x-ray optics (mostly original to the beamline and more than 20 years old) to modern state-of-the-art systems that can take full advantage of the new upgraded APS source. These new optics will provide smaller, more intense x-ray beams and improved beam stability.

This project will replace the focusing optics with new KB-style horizontal and vertical focusing mirrors and the monochromator with a new system with both silicon and multilayer optics to provide both energy resolution and high flux. The upgrade is expected to take ~2 years to complete and user operations will continue unhindered while it is taking place.

BioCAT scientist Weikang Ma was awarded a five year $2 million grant from the NIH to study inherited cardiac conditions.

When it comes to keeping hearts pumping, Illinois Institute of Technology Research Assistant Professor and BioCAT scientist Weikang Ma continues to show that he is prepared to make a significant impact.

Ma has published a pair of papers—one in Proceedings of the National Academies of Science (PNAS) and another in PNAS Nexus—and also received a $2 million grant from the National Institutes of Health to further his research into inherited cardiac conditions since December 2023.

Both papers were published in February. The first, titled “Myosin in Autoinhibited Off State(s), Stabilized by Mavacamten, Can Be Recruited in Response to Inotropic Interventions,” was published in PNAS by Ma, Illinois Tech Professor of Biology and Physics Thomas Irving, Henry Gong (Ph.D. BIOL ’22), and a team of scientists from Bristol Myers Squibb, Cardiac Consulting, the Institute for Information Technologies, and FilamenTech. The second, titled “The Structural Off and On States of Myosin Can Be Decoupled from the Biochemical Super- and Disordered-Relaxed States,” was published in PNAS Nexus by Ma, Irving, and Gong, along with scientists from Johns Hopkins University …

BioCAT offered its third MuscleX workshop entitled “Sarcomeric regulation mechanisms in health and disease” from May 18 -19 2023. This entirely virtual workshop had 200 registered attendees.

BioCAT offered its third MuscleX workshop entitled “Sarcomeric regulation mechanisms in health and disease” from May 18 -19 2023. This entirely virtual workshop had 200 registered attendees. The workshop started with an introductory presentation of the scientific missions supported at BioCAT followed by a series of 13 scientific presentations highlighting recent muscle studies using x-ray diffraction and/or other structural techniques. Topical areas that were covered were 1) Thick filament-based regulation, 2) New insights into thin filament regulation, 3) Titin and muscle regulation, 4) MyBPC and regulation of thick and thin filament, and 5) Translational studies on structural bases of muscle diseases. Speakers came from several US states, the UK, Italy and Germany. Of the 13 speakers, eight of them were at an early career stage. Speakers included Thomas Irving (BioCAT, APS, USA), Weikang Ma (BioCAT, APS, USA), Yanhong Wang (King’s College London, UK), Ilaria Morotti (U Florence, Italy) , Saffie Mohran (University of Washington, USA),Neil Kad (University of Kent, UK), Davide Tamborrini (Max Planck Institute of Molecular Physiology, Germany), Anthony Hessel …

BioCAT held its ninth intensive HOW-TO course in BioSAXS from 2/28/22-3/3/23 with 32 remote participants. There were four days of lectures and hands-on software tutorials on the basics of BioSAXS data collection and processing from expert practitioners in the field. Participants could elect to mail in samples for data collection prior to the course, and roughly half of them sent research samples and were able to analyze their own data as part of the workshop.

Some of the participants and instructors at the Everything BioSAXS 8 Workshop.

BioCAT held its ninth BioSAXS training course from 2/28/22-3/3/23. There were 32 remote participants and 8 instructors. The workshop was held entirely online, via Zoom, for ~5 hours each day. Before the workshop started, participants were able to mail samples to BioCAT for SAXS data collection. This data was then sent to them, and they were able to analyze it as part of the workshop.

Day one started off with an excellent overview of the basic physics of SAXS and what kind of information you can obtain from the technique by Dr. Richard Gillilan (BioSAXS beamline, CHESS). This was followed by a talk from …

BioCAT held its eight intensive HOW-TO course in BioSAXS from 6/21/22-6/24/22 with 36 remote participants. There were four days of lectures and hands-on software tutorials on the basics of BioSAXS data collection and processing from expert practitioners in the field. Participants could elect to mail in samples for data collection prior to the course, and roughly half of them sent research samples and were able to analyze their own data as part of the workshop.

Some of the participants and instructors at the Everything BioSAXS 8 Workshop.

BioCAT held its eighth BioSAXS training course from 6/21/22-6/24/22. There were 36 remote participants and 8 instructors. The workshop was held entirely online, via Zoom, for ~5 hours each day. Before the workshop started, participants were able to mail samples to BioCAT for SAXS data collection. This data was then sent to them, and they were able to analyze it as part of the workshop.

Day one started off with an excellent overview of the basic physics of SAXS and what kind of information you can obtain from the technique by Dr. Richard Gillilan (BioSAXS beamline, CHESS). This was followed by a talk from …

To promote the use of two NIH P30 Centers that are National Resources for the study of striated muscle; the Biophysics Collaborative Access Team (BioCAT: funded by NIGMS) at Argonne National Laboratory and the Center for Translational Muscle Research (CTMR: funded by NIAMS) are offering Multiscale Structural and Functional Studies for Striated Muscle workshop following the Myofilament Meeting in Madison Wisconsin.

The goal of this workshop is to inform investigators about the resources and expertise that these two Centers can provide, and to discuss what other resources and services would be most useful. The workshop will take place on May 24th from 1:30 pm to 4 pm at Madison Monona Terrace. See the schedule below for details.